March 2022
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Fantastic collaboration with Bernardes group, iMM, AstraZeneca, CIC BioGUNE & CIBIR
Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry J. Am. Chem. Soc. 2022, doi.org/10.1021/jacs.1c07675 |
February 2022
Our group has been awarded a research grant from the Mizutani Foundation for Glycoscience (Japan) to study a novel class of fluorescent cancer vaccines based on Carbon Dots-MUC1 conjugates. Thank you!!
October 2021
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Stressed out biomolecules react faster! Check out our new work in collaboration with G. J. L. Bernardes and Tuomas P. J. Knowles.
J. Am. Chem. Soc. 2021, 143, 40, 16401–16410. |
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September 2021
Foivos Lazaris has joined the group as a PhD student (H2020-MSCA-ITN-2020, DIRNANO project, number: 956544). Welcome!
December 2020
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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody has been published in Chemical Communications
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November 2020
Óscar Suárez García has joined the group as a PhD student (FPI2019 contract). Welcome!
September 2020
Marina Salas Cubero has joined the group as a PhD student thanks to a AECC fellowship. Welcome!
May 2020
Fayna García-Martín, who has been working in the group of Prof. S.-I. Nishimura (Hokkaido University, Japan), has joined the group as a 'Beatriz Galindo Senior' researcher. Welcome!
March 2020
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A MUC1-like glycopeptide bearing an unnatural sugar moiety boosts a robust immune response in mice.
Chem. Sci. 2020, 11, 3996-4006. |
February 2020
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A cool collaboration with Prof. Ben G. Davis and Emilio J. Cocinero on the conformational preferences of putative DNA-Scaffold Ribosugars in the gas phase and in water solution.
ACS Cent. Sci. 2020, 6, 293-303. About the Cover: Unprecedented atomic resolution structural gas-phase and solution-phase analysis chemically and precisely dissects DNA's subtle backbone conformations using atom-by-atom, isotopologue-by-isotopologue spectroscopy. |
January 2020
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A very nice collaboration with Ramón Hurtado-Guerrero on on the molecular mechanism for GalNAc-T3 glycosylation of FGF23. Nat. Chem. Biol. 2020, doi:10.1038/s41589-019-0444-x.
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February 2019
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Our paper on structure-based design of potent tumor-associated antigens for vaccine applications was just accepted in JACS. Congrats to our student Ismael Compañón and the whole team!
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December 2018
Congrats to Dr. Ester Jiménez-Moreno from Bernardes Lab (University of Cambridge).
She has been awarded a two-year postdoc fellowship from our university to work on the development of new biosensors, based on glycoprotein MUC1, to detect tumor cells in sera of cancer patients.
August 2018
Another JACS paper of the group ( J. Am. Chem. Soc. 2018, 140, 9952-9960) has been highlighted in JACS Spotlights: "Water Sculpts the Distinctive Shapes and Dynamics of the Tn Antigens: Implications for their Molecular Recognition",
J. Am. Chem. Soc. 2018, 140, 10383−10384.
J. Am. Chem. Soc. 2018, 140, 10383−10384.
June 2018
I have been invited to give a talk at "II Meeting CINBIO". Biomedical Research Centre. Science Fac. University of Vigo. 25-26 June 2018.
March 2018
Congrats to our PhD student Alicia Asin. She has been awarded a grant from "Spanish Association Against Cancer" (AECC-La Rioja) to work on the development of new biosensors.
January 2018
Our paper "The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer" has been highlighted in JACS Spotlights: J. Am. Chem. Soc.2018, 140, 1–1.
November 2017
Two JACS papers accepted this productive and exciting month!! Both of them in collaboration with GBernardesLab
... and a Nature Communications paper with Ramón Hurtado-Guerrero.
... and a Nature Communications paper with Ramón Hurtado-Guerrero.
- The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer
- Chemoselective Installation of Amide Bonds on Proteins through Aza-Michael ligation
- The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
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October 2017
It was my pleasure to give a talk at "XL Biochemical and Molecular Biology Society Congress ". Barcelona, 23-26 October 2017.
July 2017
- 2nd Workshop of our ITN project "ProteinConjugates" , London, 25-26 July 2017.
- I have given the oral presentation “Effect of Glycosylation on Mucin-Like Peptides and Implications for Molecular Recognition by Antibodies”, at 19th European Carbohydrate Symposium (EUROCARB2107). Barcelona, 2-6 July 2017.
June 2017
- I have been invited to give a talk at “16th Spanish Biophysical Congress” in Seville. 6-8 June 2017.
- Happy to be a member of the Organizing Committee of the Symposium “STRUCTURAL DETERMINANTS OF THE MOLECULAR RECOGNITION PROCESSES IN BIOLOGICAL MOLECULES”, XXXVI Biennial Meeting of the Spanish Royal Society of Chemistry 2017. Sitges, 25-29 June 2017.
March 2017
I have been invited to give the seminar "Design of novel glycopeptide-based cancer vaccines" at "Glycovax Training Event II", which will be held in Lisbon (20-24 March 2017).
November 2016
My Colleague Gonzalo Jiménez-Osés and I organize “The 13th Young Investigator Symposium of the Spanish Royal Society of Chemistry”. It is a great honor to invite you to attend this symposium, which will be held at Universidad de La Rioja (8-11 November 2016).
September 2016
The inaugural ProteinConjugates ITN workshop opens today (6 September 2016):
Local news reports (in Spanish) on my stay this summer at The University of Cambridge:
June 2016
I start my three-month stay at The University of Cambridge working on selective-site protein modifications at the research group of G. Bernardes.
April 2016
Xhenti Ferhati will be joining our group in May 2016 as a PhD student. She will work on anti-MUC1 antibodies conjugates as potential biosensors for detecting tumors (ProteinConjugates project).
March 2016
This Monday (14 March), I give a talk on cancer vaccines at III BIENNIAL MEETING OF THE CHEMICAL BIOLOGY GROUP / XII CARBOHYDRATE SYMPOSIUM
Local news reports (in Spanish) on our ProteinConjugates project:
This is a Youtube video (in Spanish) explaining the project:
February 2016
Francisco Corzana participates as principal investigator (PI) in the National Research Project (CTQ2015-67727-R) granted by Ministerio de Economía y Competitividad to QUIBI group (Universidad de La Rioja).
January 2016
Francisco Corzana is going to participate as invited speaker at three important meetings this year:
- International Conference on Molecular Recognition (1-3 February), Zaragoza
- III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium (14-16 March), Madrid
- 11 Spanish-Italian Symposium on Organic Chemistry (13-15 July), San Sebastian
December 2015
Francisco Corzana has been the recipient of a Salvador Madariaga grant (MEC) to perform a research stay at the University of Cambridge (UK) from 1st June to 31st August 2016. He will work at Bernardes Lab on site-selective modification of antibodies with potential applications for the treatment of cancer.
November 2015
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Francisco Corzana is part of the ProteinConjugate international consortium that was recently awarded with a 2.5 million € Marie Curie ITN grant.
The ProteinConjugates is an innovative science & training program that aims to develop new site-selective bioconjugation methodologies that explore natural amino acids and their use to build protein conjugates for the treatment of cancer, by providing advanced training to the next generation of excellent European researchers. |
